This project investigates the role of functional proteins in presynaptic neurotransmission and synaptic plasticity by combining data-driven and theory-driven modeling approaches. By focusing on parameter estimation and identifiability, the study aims to deepen our understanding of synaptic function and its alterations in neurodegeneration and sleep deprivation.
Reduced modeling scheme of presynaptic vesicle cycle. Under the influence of calcium ions and functional proteins, vesicles dock at the active zone of the presynaptic terminal, fuse in response to stimulation, and are then recycled for subsequent use.
We aim to develop a modular system of models for the various components of presynaptic neurotransmission, including calcium ion flow through channels, vesicle movement toward the membrane, vesicle recycling dynamics, and the adaptation of protein concentrations. These modules will be designed so that they can be flexibly combined with each other, allowing for tailored analyses depending on the specific research questions being addressed. A central focus will be on neurodegeneration induced by sleep deprivation: How do disruptions in sleep-related processes affect synaptic function over time, and what role do functional proteins play in mediating or mitigating these effects?
